Helper-independent retrovirus vectors with Rous-associated virus type O long terminal repeats.

摘要: We have constructed nonpermuted replication-competent avian retrovirus vectors that derive from Rous sarcoma virus (S. H. Hughes, J. Greenhouse, C. Petropoulos, and P. Sutrave, Virol. 61:3004-3012, 1987). describe here the construction properties of corresponding in which long terminal repeats (LTRs) parental been replaced by LTRs endogenous chicken Rous-associated type O. The O LTR replicated approximately 1/10 as well expressed a test gene, chloramphenicol acetyltransferase, 1/30 to 1/50 well. Images