Epigenetic Changes in Gliomas

摘要: Epigenetic alterations have been fundamentally implicated in the pathobiology of several malignancies including gliomas. Such changes involve tumor specific promoter methylation, histone modifications, and microRNA. Several such recently reported also seen to highly correlate with outcome highlighting their clinical significance, following: Promoter methylation MGMT correlates improved survival glioblastoma patients who receive chemoradiation therapy anaplastic glioma treated radiation alone as frontline therapy. A CpG island methylator phenotype (G-CIMP) confers better proneural subtype glioblastoma. Mutations IDH1 are commonly early events low grade gliomas associated a hypermethylator phenotype. H3F3A which encodes variant H3.3 pediatric high turn linked reduction H3 lysine trimethylation mark (H3K27me3) possibly DNA hypomethylation mechanisms for activated gene expression. Lastly, altered expression microRNA has biology. These findings point rapidly expanding recognition critical role epigenetic gliomagenesis pathobiology. This given rise trials that either utilize prognostic markers patient stratification or attempts at therapeutic targeting states However, much remains be learned about complex interplay between various factors cells influence on genetic alterations; insights will provide foundation strategies aimed modulating target