Genetically Engineered Mouse Models of Brain Cancer and the Promise of Preclinical Testing

摘要: Recent improvements in the understanding of brain tumor biology have opened door to a number rational therapeutic strategies targeting distinct oncogenic pathways. The successful translation such “designer drugs” clinical application depends heavily on effective and expeditious screening methods relevant disease models. By recapitulating both underlying genetics characteristic tumor-stroma microenvironment cancer, genetically engineered mouse models (GEMMs) may offer advantages over cell culture xenograft systems preclinical testing promising therapies. This review focuses recently developed GEMMs for glioma medulloblastoma, discusses their potential use trials. Examples showcasing molecularly targeted therapeutics are given, topics, as stem biology, vivo imaging technology radiotherapy, also addressed.