Hereditary Predisposition to Primary CNS Tumors

摘要: The majority of primary central nervous system (CNS) tumors in children and adults occur sporadically, i.e., patients with an unremarkable family history no clinical evidence a hereditary disorder, such as tumor predisposition syndrome. Nevertheless, some brain arise the setting syndromes, neurofibromatosis, underlying condition is often not recognized until after diagnosed. Tumors arising syndromes sometimes have different biological behavior compared to their sporadic counterparts, afflicted may require additional treatments or screening, multiple members be affected. Therefore, it important for those involved diagnosis, treatment follow-up knowledgeable about known predispositions relevant this population. As genome-wide sequencing increasingly applied, can expected that CNS will identified near future.