Neurofibromatosis type 1 - a model for nervous system tumour formation?
作者： Joshua B. Rubin , David H. Gutmann
DOI: 10.1038/NRC1653
关键词: Genetically Engineered Mouse 、 Genetic Condition 、 Cancer research 、 Nervous system 、 Disease 、 Neurofibromatosis 、 Biology 、 Extramural 、 Tumor formation 、 Malignant progression
摘要: Neurofibromatosis type 1 (NF1) is a common genetic condition in which affected individuals develop benign and malignant nervous system tumours. Genetically engineered mouse (GEM) models of these NF1-associated tumours recapitulate several the unique clinical aspects disease. Moreover, Nf1 GEM allow for direct examination earliest stages tumour evolution, including contributions that Nf1(+/-) cellular elements cooperating changes make to facilitate transition from pre-neoplastic neoplastic state and, some cases, promote progression.
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