Chemokines and primary brain tumors
作者： Shyam S. Rao , Mahil Rao , Nicole Warrington , Joshua B. Rubin
DOI: 10.1007/978-1-4419-0793-6_11
关键词:
摘要: Normal development of the central nervous system (CNS) is critically dependent upon coordinated expression chemokines and their receptors in a spatially temporally regulated fashion (reviewed Klein Rubin 2004; Li Ransohoff 2008). During development, control progenitor cell migration (Bagri et al. 2002; 2001; Lu 2001), proliferation (Klein survival (Chalasani 2003a) as well modulate differentiated functions such axon pathfinding fasciculation 2003b; Chalasani 2007). Thus, it should not be surprising to discover that also contribute biology CNS neoplasms. In this chapter we will primarily review studies have defined role one chemokine, CXCL12, its receptor, CXCR4, play brain tumor how pathway being targeted for therapy. addition, touch on tumor-derived recruitment inflammatory cells sites growth.
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