Review: insights gained from modelling high-grade glioma in the mouse.

作者: S. L. Rankin , G. Zhu , S. J. Baker

DOI: 10.1111/J.1365-2990.2011.01231.X

关键词:

摘要: High grade gliomas (HGG) are devastating primary brain tumors with universally poor prognoses. Advances toward effective treatments require improved understanding of pathogenesis and relevant model systems for preclinical testing. Mouse models HGG provide physiologically experimental analysis pathogenesis. There advantages disadvantages to the different methodologies used generate such models, including implantation, genetic engineering or somatic gene transfer approaches. This review highlights how mouse have provided insights into contribution specific mutations tumor initiation, progression, phenotype, influence microenviroment, cell types that can give rise glioma. HGGs a highly heterogeneous group tumors, complexity diverse within common signaling pathways as well developmental cell-type context transformation contribute overall diversity glioma phenotype. Enhanced giving HGG, along ability design increasingly complex more closely approximate process human gliomagenesis will continue dissecting mechanisms disease

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