Genetic determinants of malignancy in a mouse model for oligodendroglioma.

摘要: Oligodendrogliomas of all grades overexpress epidermal growth factor receptor ( EGFR ), whereas deletion ink4a/arf is found only in high-grade tumors. We used the S100β promoter to generate transgenic mice expressing v-erbB , a transforming allele . These developed low-grade oligodendroglioma. Transgenic animals heterozygous for or p53 Comparative genomic hybridization revealed loss distal mouse chromosome 4, region orthologous with human 1p, which commonly lost Our results demonstrate that overexpression an epigenetic observation uncertain significance oligodendroglioma, can initiate oligodendroglioma mouse. Furthermore, pathway mutations mediate transition from low high grade. models hold promise studying tumor lineage, identifying contributing genetic alterations and evaluating preclinical therapies this important neoplasm.