Evidence for a Tumor Suppressor Gene on Chromosome 19q Associated with Human Astrocytomas, Oligodendrogliomas, and Mixed Gliomas

摘要: Abstract Previous studies have shown frequent allelic losses of chromosomes 9p, 10, 17p, and 22q in glial tumors. Other researchers briefly reported that tumors may also show chromosome 19, suggesting a putative tumor suppressor gene locus on this (D. T. Ransom et al. , Proc. Am. Assoc. Cancer Res., 32: 302, 1991). To evaluate whether loss 19 alleles is common different types grades, we performed Southern blot restriction fragment length polymorphism analysis for multiple loci 122 gliomas from 116 patients. Twenty-nine had constitutional heterozygosity 19q, four partial deletions 19q. Allelic 19q were restricted to grade III anaplastic astrocytomas (4/9) IV glioblastomas (11/46), II oligodendrogliomas (2/5) (2/2), (5/8) (5/7) mixed oligoastrocytomas. These data demonstrate genetic similarities between astrocytomas, oligodendrogliomas, indicate the presence