The Molecular Biology of Diffuse Low-Grade Gliomas
作者： Nicholas F. Marko , Robert J. Weil
DOI: 10.1007/978-1-4471-2213-5_8
关键词: Translational research 、 Oligodendroglioma 、 Tumor biology 、 World health 、 Astrocytoma 、 Grading (tumors) 、 Oligoastrocytoma 、 Epigenomics 、 Medicine 、 Molecular biology
摘要: The World Health Organization (WHO) grading scheme for glial neoplasms assigns grade II to three infiltrating (non-circumscribed) gliomas: diffuse astrocytomas, oligodendrogliomas, and oligoastrocytomas. Although commonly referred collectively as among the “low-grade gliomas”, these tumors represent molecularly clinically unique entities. Each is subject of active basic research aimed at developing a more complete understanding its molecular biology, pace such continues accelerate. Additionally, because prognostication management has historically proven challenging, translational regarding gliomas in hopes identifying novel features that can better inform diagnostic, prognostic, therapeutic strategies. Unfortunately, literature biology WHO remains nebulous. Our goal this chapter present comprehensive discussion current knowledge characteristics on chromosomal, genomic, epigenomic levels. we discuss emerging evidence suggesting differences between adult pediatric low-grade, gliomas. Finally, an overview strategies using data classify into relevant categories based tumor biology.
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