The Contribution of Genetic and Epigenetic Mechanisms to Gene Silencing in Oligodendrogliomas

摘要: Very little is known of the genes and mechanisms contributing to genesis oligodendrogliomas, a subtype primary brain tumors. Using an integrated genetic epigenetic analysis we show that aberrant CpG island methylation most prevalent alteration in these tumors, majority methylated are independent regions affected by deletion. In contrast, subset gene-associated islands preferentially converging deletion, including putative zinc finger gene, ZNF342, located commonly deleted region at chromosome 19q13. ZNF342 expression specifically decreased oligodendrogliomas up-regulated glioma cell lines treated with demethylating agent, whereas level adjacent Gemin7, not consistently altered samples. This initial approach identifies novel targets gene silencing, provides more comprehensive view underlying oligodendrogliomas.