Chromosome 9 deletion mapping reveals interferon alpha and interferon beta-1 gene deletions in human glial tumors.

摘要: We have applied restriction fragment length polymorphism analysis to a 30-member panel of primary glioma DNAs, which had been previously examined for loss genetic information (C. D. James, E. Carlbom, J. P. Dumanski, M. Hansen, Nordenskjold, V. Collins, and W. K. Cavenee, Cancer Res., 48:5546-5551, 1988), determine the frequency sublocalization from chromosome 9. also utilized scanning densitometry dosage determination 9p-localized interferon alpha beta-1 genes among these same tumors. Our results reveal following: (a) those cases in has occurred, region common lies on short (p) arm chromosome; (b) 9 occurs frequently glial tumors intermediate (anaplastic, grade III) high (glioblastoma, IV) histological malignancy (10 20 cases) but not low (grade II) (0 10 cases); (c) with 9p deletions are hemi- or nullizygous gene cluster; (d) nullizygosity occur exclusively highest (glioblastoma). These data, especially nullizygosity, suggest proximity residence within gene(s) whose function(s) is (are) critical suppression malignant evolution