Molecular genetic characterization of CNS tumor oncogenesis.

摘要: Publisher Summary This chapter presents the accumulated data from molecular genetic analyses of human central nervous system (CNS) tumors and compares these with tumor evolution model Nowell by using histopathologically assessed malignancy such as an indicator their stage malignant progression. The considers level resolution that has been obtained toward understanding nature CNS neoplasia significance research clinical diagnosis treatment tumors. histopathological indicators biological aggressiveness have empirically determined through comparison morphology corresponding patient outcome. describes investigations represent preliminary attempts identification genes whose alteration is causally associated development neoplasia, characterization alterations, functional consequences alterations. changes confer cells increasing growth advantage exposes mechanisms cellular proliferation; processes fundamental to altering them providing promise for management cancer.