Molecular genetic approach to human meningioma: loss of genes on chromosome 22

摘要: Abstract A molecular genetic approach employing polymorphic DNA markers has been used to investigate the role of chromosomal aberrations in meningioma, one most common tumors human nervous system. Comparison alleles detected by tumor versus from normal tissue revealed alterations present primary surgical specimens. In agreement with cytogenetic studies cultured meningiomas, frequent alteration was loss heterozygosity on chromosome 22. Forty 51 patients were constitutionally heterozygous for at least 22 marker. Seventeen 40 heterozygotic (43%) displayed hemizygosity corresponding marker their meningioma tissues. Loss also a significantly lower frequency several other autosomes. view striking association between acoustic neuroma and bilateral neurofibromatosis discovery that neuromas display specific genes 22, we propose mechanism involving is operative development both types. Fine-structure mapping reveal partial deletions meningiomas may provide means clone characterize gene (or genes) importance tumorigenesis this possibly clinically associated