Glioblastoma multiforme and anaplastic astrocytoma. Pathologic criteria and prognostic implications.

摘要: A total of 1440 malignant astrocytic gliomas from three Phase III trials the National Brain Tumor Study Group were studied to document clinical usefulness subclassifying these lesions as either an anaplastic astrocytoma or a glioblastoma multiforme. As defined by previous "blind" pathology review, two groups patients compared mean age, duration preoperative symptoms, and postrandomization survival. In addition, 10 histologic variables in 150 with establish internal correlations, relate specific patient age There highly significant differences post randomization survival between groups. Internal correlations disclosed statistically associations presence lymphocytes gemistocytic astrocytes. It is concluded that subclassification into multiforme defines are significantly different regard length The problems tissue sampling recognized, however, assignment, blind such indicates classification has utility for large randomized trials. analysis astrocytomas confirms suggestions gemistocytes frequently coexist gliomas, but this study inflammatory cells did not appear influence reemphasizes association advancing shorter survivals gliomas.