Necrosis as a prognostic criterion in malignant supratentorial, astrocytic gliomas
作者： J. S. Nelson , Y. Tsukada , D. Schoenfeld , K. Fulling , J. Lamarche
DOI: 10.1002/1097-0142(19830801)52:3<550::AID-CNCR2820520327>3.0.CO;2-C
关键词: Pathology 、 Median survival 、 Coagulative necrosis 、 Necrosis 、 Astrocytic Tumor 、 Medicine 、 Treatment protocol 、 Glioblastoma 、 Prognostic factor 、 Astrocytoma 、 Cancer research 、 Oncology
摘要: Surgical specimens of malignant, supratentorial, astrocytic gliomas from 503 patients randomized on an RTOG-ECOG treatment protocol were examined by central pathologic review. The diagnosis glioblastoma multiforme (GBM) was made only when one or more foci coagulation necrosis involving tumor cells identified histologically. Malignant neoplasms without classified as astrocytoma with atypical anaplastic features (AAF). median survival stratifying for GBM eight months compared to 28 AAF. In most cases the received a Kernohan grade. On basis these grades, Grade 3 had ten nine those 4. Observations demonstrate that is reliable, decisive prognostic factor associated gliomas. system limited value in assessing prognosis this group tumors.
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