Patterns of Tumor Progression Following BNCT of Glioblastoma Multiforme

摘要: The recurrence patterns after conventional adjuvant treatment of glioblastoma multiforme has been analyzed in the past. most consistent pattern seen these studies is predominance local recurrence.1,2,3 Hochberg and Pruitt were first investigators to discover that gross microscopic tumors within 2 cm contrast-enhancing tumor margin on pre-terminal CT scans 83% patients.3 This became basis for target volume definition radiotherapy. In several BNCT protocols, this was adopted. However, there considerable consternation over significance peritumoral edema when planning radiation fields. Biopsy autopsy from Mayo Clinic Duke University have shown infiltrating cells edematous regions.1,2 If so, hypodense regions may be at risk should included volume. observation still dispute because malignant nature not proven. by Wallner et al. Memorial Sloan Kettering Cancer Center, no tendency areas shown.4 present paper reports our trial, particular, with relation edema.