Cytogenetic analysis of 109 pediatric central nervous system tumors
作者： Paul Steinbok , D.Douglas Cochrane , Karen Goddard , Etela Neumann , Dagmar K. Kalousek
DOI: 10.1016/0165-4608(93)90200-6
关键词: Ependymoma 、 Chromosome 7 (human) 、 Pathology 、 Cytogenetics 、 Central nervous system disease 、 Choroid plexus 、 Biology 、 Karyotype 、 Monosomy 、 Immunology 、 Chromosome
摘要: Reports of cytogenetic abnormalities in pediatric central nervous system (CNS) tumors are important for collection and comparison large numbers karyotypes primary CNS neoplasms to produce statistically significant correlations. We report results 119 samples from 109 patients. Tumors included 33 low-grade astrocytomas, 18 high-grade 14 gangliogliomas, 13 ependymomas, 17 primitive neuroectodermal (PNET), three choroid plexus papillomas carcinomas, a miscellaneous group 20 rare metastases. In each group, were correlated with histologic subtype survival. The study indicated specific chromosome different groups tumors. Low-grade astrocytomas showed mostly numeric gains 7, differences karyotypic changes observed adults lacking double minutes (dmin) monosomy 10. ependymoma the largest proportion abnormal frequent involvement 6 16. Chromosome was single most common this study, closely followed by chromosomes 1 11. Pediatric differ adult cytogenetically as well histologically biologically.
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sci-hub.se 参考文章(35)
C. David James, V. Peter Collins, Molecular genetic characterization of CNS tumor oncogenesis. Advances in Cancer Research. ,vol. 58, pp. 121- 142 ,(1992) , 10.1016/S0065-230X(08)60293-6
Garrett M. Brodeur, Bert Vogelstein, Darell D. Bigner, David Sidransky, Henry S. Friedman, Sandra H. Bigner, Robert L. Saylors, Infrequent p53 gene mutations in medulloblastomas. Cancer Research. ,vol. 51, pp. 4721- 4723 ,(1991)
Darell D. Bigner, Dennis E. Bullard, Joachim Mark, Peter C. Burger, Lawrence H. Muhlbaier, Sandra H. Bigner, M. Stephen Mahaley, Specific Chromosomal Abnormalities in Malignant Human Gliomas Cancer Research. ,vol. 48, pp. 405- 411 ,(1988)
Richard M. Cawthon, Carolyn A. Pedone, Douglas Brockmeyer, Dan Fults, Micam W. Tullous, p53 mutation and loss of heterozygosity on chromosomes 17 and 10 during human astrocytoma progression. Cancer Research. ,vol. 52, pp. 674- 679 ,(1992)
Beverly S. Emanuel, Lucy B. Rorke, Constance A. Griffin, Anita L. Hawkins, Roger J. Packer, Chromosome abnormalities in pediatric brain tumors. Cancer Research. ,vol. 48, pp. 175- 180 ,(1988)
Chromosome 1 Abnormalities: A Common Feature of Pediatric Solid Tumors Journal of the National Cancer Institute. ,vol. 75, pp. 51- 54 ,(1985) , 10.1093/JNCI/75.1.51
Vogelstein B, Bigner Dd, Friedman Hs, Bigner Sh, Oakes Wj, Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts. Cancer Research. ,vol. 50, pp. 2347- 2350 ,(1990)
Gundula Thiel, Tanka Losanowa, Dieter Kintzel, Gunter Nisch, Hubert Martin, Klaus Vorpahl, Regine Witkowski, Karyotypes in 90 human gliomas Cancer Genetics and Cytogenetics. ,vol. 58, pp. 109- 120 ,(1992) , 10.1016/0165-4608(92)90095-P
R. Casalone, P. Simi, Paola Granata, E. Minelli, A. Giudici, G. Butti, C.L. Solero, Correlation between cytogenetic and histopathological findings in 65 human meningiomas Cancer Genetics and Cytogenetics. ,vol. 45, pp. 237- 243 ,(1990) , 10.1016/0165-4608(90)90088-R
Pamela S. Karnes, Tuan N. Tran, Mei Ying Cui, Corey Raffel, Floyd H. Gilles, John A. Barranger, Kuang Lin Ying, Cytogenetic analysis of 39 pediatric central nervous system tumors. Cancer Genetics and Cytogenetics. ,vol. 59, pp. 12- 19 ,(1992) , 10.1016/0165-4608(92)90150-7