Mitotic recombination of chromosome 17 in astrocytomas.

摘要: Abstract Allelic combinations at seven loci on human chromosome 17 defined by restriction fragment length polymorphisms were determined in tumor and normal tissues from 35 patients with gliomas. Loss of constitutional heterozygosity one or more these was observed 8 the 24 tumors displaying astrocytic differentiation single primitive neuroectodermal examined. The astrocytomas showing losses included examples each adult malignancy grade disease, including glioblastoma (malignancy IV), them demonstrated concurrent maintenance for least locus. Determination allele dosage together genotypic data indicated that chromosomes derived mitotic recombination 7 9 cases shared homozygosity region 17p11.2-pter all cases. In contrast, oligodendrocytic, ependymal, mixed cellular did not exhibit loss alleles any These suggest somatic attainment 17p is frequently associated oncogenesis central nervous system tumors, particularly those solely differentiation, mapping a useful approach towards subregional localization locus whose rearrangement involved this disease.