Clinicopathological correlation of cell proliferation, apoptosis and p53 in cerebellar pilocytic astrocytomas.

摘要: We have analysed 78 cerebellar pilocytic astrocytomas to assess whether histopathology, cell proliferation. apoptosis rate, p53 immunoreactivity, or flow cytometry could predict their long-term behaviour. Classic pilocytic/ microcystic pattern was seen in 62 patients and 16 had mixed with an additional non-pilocytic glial component. The overall 5-year survival 93%, complete resection providing 100% survival. four who died during the follow-up were more than 14 years of age, primary operation been incomplete three them variants. In 15 cases tumour recurred giving a recurrence free 77%. proliferation indices low: Ki-67 MIB-1 (median 2.0%), PCNA (1.2%) S-phase fraction (4.4%). -labelling index significantly higher young patients, but did not differ between classic Twenty-two per cent tumours aneuploid diploid tumours, seems act as 'guardian genome' astrocytomas, because aberrant/increased expression aneuploidy associated enhanced apoptosis. Only patient age (P=0.01), radicality (P=0.0001) histology (classic vs mixed, P=0.008) correlated poorer prognosis ol variant suggests that this may represent distinct entity. Although none novel parameters predicted survival, they indicate substantial biological variation among astrocytomas.