Prognostic implications of p53 protein, epidermal growth factor receptor, and Ki-67 labelling in brain tumours.

摘要: The expression of p53 protein, epidermal growth factor receptor (EGFR), and Ki-67 nuclear antigen was examined by immunohistochemistry in biopsies 16 types human brain tumours, including 43 astrocytomas. P53 almost certainly its mutant form, expressed seven the 16, EGFR 11 tumours. In astrocytomas both proportion tumours which or increased with grade malignancy as did mean labelling index (LI): p53-0% 1, 17% 2, 38% 3, 65% 4; EGFR-0% 33% 85% 95% L1-1.1% grades 1 8.3% 13.4% 4. Astrocytomas had a significantly higher LI at P less than 0.05 (11.8% 10.7%, resp.) those that not (6.2% 4.1%, resp.). Patients expressing reduced survival (P = 0.035 0.007, resp.): only 11% + ve 13% patients were alive 100 weeks following diagnosis compared to 36% p53-ve 60% EGFR-ve patients. greater 5% 0.0001)--none survived beyond 86 diagnosis, whilst 63% positive cells still weeks. univariate analysis showed mutants, are associated malignant progression poor prognosis. multivariate revealed tumour Ki-67LI independent prognostic factors for survival.