The efficacy and distribution of suramin in the treatment of the 9L gliosarcoma.

摘要: Suramin inhibits the stimulation of brain tumor deoxyribonucleic acid synthesis in vitro at concentrations 200 to 400 mg/ml. This report evaluates suramin rodent 9L model. Survival was analyzed by treating 10 tumor-bearing animals with (7 mg/kg/d intraperitoneally) for 7 days, beginning 1 week after implantation, and compared 20 untreated animals. Tissue distribution reverse-phase high-pressure liquid chromatography homogenized organs normal Tumor concentration measured over time treated a range doses, 2 weeks implantation. imparted no benefit as control survived 24.7 +/- 3.4 days 24.5 1.5 respectively. In receiving mg/kg/d, renal were highest--339.8 30.9 mg/g late 25 treatment. Concentration peaked only 3.3 1.3 days. 74.4 16.5 day last injection, significantly less than estimated studies efficacy. After injections 35 levels reached 230.9 139.2 evidence inhibition progression. The response mg/kg direct inoculation assessed saline control. Animals died 3 hours. Intracerebral hematoma volume injection site 13.9 10.7 mm3 1.9 3.32 suramin-treated animals, respectively (P = 0.02), confirming reported anticoagulant activity suramin. is without efficacy model because poor systemic delivery. Alternative results lethal local hemorrhage. Further consideration necessary before broad clinical application this drug.