Molecular Pathology of Nervous System Tumors

摘要: In modern clinical neuro-oncology, no variable affects therapeutic decisions and prognostic estimation more than tumor classification. The most widely used method of brain classification is that the World Health Organization (WHO), recently revised in 2000 (51), which based on microscopic examination tissue by a pathologist. WHO divides nervous system tumors into many nosological entities (Table 1) assigns grade I to IV, being benign IV highly malignant. Although, majority cases, assignment relevant appropriate, unfortunately there are situations this problematic, primarily because pathological diagnosis remains quite subjective (67). For example, some difficult place neatly one categories. others, histological corresponding predicted behavior do not concur with actual course. Finally, it doubtful current histopathological alone will accurately predict patient response targeted therapies once available. As such, information capable augmenting could result marked improvements approach