Chromosome 1p and 14q FISH analysis in clinicopathologic subsets of meningioma: diagnostic and prognostic implications.

摘要: The second most frequently reported genetic abnormalities in meningiomas after 22q loss are deletions of Ip and 14q. To assess the potential diagnostic prognostic utility these chromosomal alterations, we studied 180 well-characterized using dual-color fluorescence situ hybridization (FISH) with DNA probes localized to 1p32. 1p36, 14q13, 14q32. Our cohort consisted 77 benign (grade I), 74 atypical II), 29 anaplastic III) meningiomas. Benign were further stratified into subsets recurring (despite gross total resection) vs non-recurring (at least 10 yr follow-up) mitotically active brain invasive subsets, respectively. Losses 14q losses identified 23% 31% benign, 56% 57% atypical, 75% 67% meningiomas, respectively (p < 0.001 for 1p; p = 0.004 14q). Combined 1p/14q encountered 7% 39% 63% 0.001), less likely harbor than examples (17% 50%, 0.013). There was a trend combined have poorer overall survivals, though neither reached statistical significance. We conclude that I highly associated increasing histologic grade play an important role meningioma tumor progression. Furthermore, FISH analysis may aid assessing recurrence risk histologically