Progesterone and glucocorticoid receptor activation in meningiomas.

摘要: THE POSSIBILITY THAT the female sex steroid progesterone plays a role in meningioma proliferation has been suggested by number of investigators, and it shown that many meningiomas have high-affinity binding sites. There long-standing debate literature as to whether receptors are present functional. We recently showed, use immunohistochemistry, receptor is localized nucleus, suggesting location be activated. In this study, eight cell cultures were transiently transfected with construct contains two palindromic progesterone/glucocorticoid response elements front thymidine kinase promoter chloramphenicol acetyl sequence tyrosine aminotransferase gene. all cultures, an increase transcription element was observed presence dexamethasome, glucocorticoid An addition promegestone (R5020), agonist, only expressing receptor. These data show both functional support concept progestins glucocorticoids may play important growth. (Neurosurgery 37 :92-97, 1995)