Sex steroid and epidermal growth factor profile of giant meningiomas associated with pregnancy

摘要: Abstract Background An association between meningioma, breast cancer, and increased growth of meningiomas during pregnancy, the luteal phase menstrual cycle have been shown in previous reports, but mechanisms still remain unclear. These data suggest that sex steroids factors may a role meningiomas. This is an important factor to consider development more effective nonsurgical treatment options. Methods We described 3 patients with meningioma who presented early postpartum period. The lesions were completely resected, immunohistochemical evaluation PR, ER, EGF receptor, Ki67 antigen was performed. Results Pathologic studies tumor specimens revealed atypical (grade 2), syncytial 1), transitional-psammomatous for cases 1, 2, 3, respectively. Immunohistochemical demonstrated positive PR staining all cases, there no immunostaining ER any cases. Immunohistochemistry receptor showed membranous less than 10% cells, 50% resulted 20% cells case 5% 3. Conclusions Although many reports indicating pregnancy published, number limited. study suggested importance targeting antigen, therapeutic regimens.