Comparative genomic hybridization analysis of genetic alterations associated with malignant progression of meningioma.
作者： Satoshi Ozaki , Takafumi Nishizaki , Haruhide Ito , Kohsuke Sasaki
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摘要: Little is known about genetic alterations during malignant progression of meningioma. We used comparative genomic hybridization (CGH) in 20 patients (13 with typical, 4 atypical and 3 anaplastic meningiomas) to investigate the pathway underlying development Typical meningiomas displayed only a few changes such as monosomy 22. Anaplastic manifested more aberrations than typical meningiomas, frequently exhibiting losses 1p, 2p, 6q, chromosome 10 14q, gain 20q, addition The average number alteration sites each patient meningioma was significantly less those (p < 0.01) 0.05). showed chromosomal seen together other aberrations. These CGH findings suggest that 20q are implicated
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