Biological behavior and tumorigenesis of subependymal giant cell astrocytomas.

摘要: In spite of the benign nature subependymal giant cell astrocytomas (SEGAs), some show massive hemorrhage, rapid growth, and tumor recurrence. This led us to investigate biological behavior, dynamics, tumorigenesis SEGAs. All patients (4 men 3 women; age range, 6-27 years; mean, 13.6 years) had features tuberous sclerosis complex obstructive hydrocephalus. One patient intratumoral bleeding. two patients, sequential neuroimaging showed a nodule growing become SEGA. underwent surgical resection without radiation therapy. recurred was treated surgically. There were no postoperative deaths. The presence cytologic atypia, mitoses vascular proliferation implication in terms clinical course. MIB-1 labeling indices low (mean, 0.9), indicating proliferative potential. Unexpectedly, bcl-2 staining sparse bax predominated majority cases. However, mean value terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end index low. Immunohistochemically, tumors positive for both glial neuronal markers. our cases, expression p53 Only one focally tuberin. SEGAs have potential apoptotic activity, exhibit mixed glial-neuronal differentiation. contrast p53, tuberin is suggested be suppressor this tumor.