Cisplatin and BCNU chemotherapy for anaplastic oligoastrocytomas.

摘要: In this study 32 newly diagnosed anaplastic oligoastrocytoma patients were enrolled (median age of 41 years, range 19–63; median Karnofsky performance status 90, 70–100). All treated with Cisplatin (109 mg/m2) and BCNU (160 mg/m2). The chemotherapy started in the first week after surgery it was administered every 6 weeks (5 scheduled cycles) for a total 127 cycles. After second cycle all received radiotherapy (56.5 Gy). follow-up 63.2 months (10–91). Nine reoperated-on. time to tumor progression (TTP) survival (ST) whole group 54.6 70.1 months, respectively. A proportional hazard model used look at potential prognostic factors including lower (< 40 years), extent (total/subtotal versus partial) reoperation. When we analyzed total/subtotal or under 40 years ST could not be assessed due high number surviving 52 months. older partially operated-on 54.1 42.2 our only predicted longer (p < 0.001). This schedule treatment provides durable response selected patients.