In vivo modeling of malignant glioma: the road to effective therapy.

摘要: Despite an increased emphasis on developing new therapies for malignant gliomas, they remain among the most intractable tumors faced today as demonstrate a remarkable ability to evade current treatment strategies. Numerous candidate treatments fail at late stages, often after showing promising preclinical results. This disconnect highlights continued need improved animal models of glioma, which can be used both screen potential targets and authentically recapitulate human condition. review examines recent developments in modeling from more established rat intriguing systems using Drosophila zebrafish that set stage higher throughput studies potentially useful targets. It also addresses versatility mouse newly developed techniques recreating protocols sophisticated genetically engineered approaches aim characterize biology gliomagenesis. The use these future will elucidate effective combination impact disease management.