Active WNT vampirization by glioblastoma network leads to brain tumor growth and neurodegeneration
作者： Marta Portela , Varun Venkataramani , Natasha Fahey-Lozano , Esther Seco , Maria Losada-Perez
DOI: 10.1101/428953
关键词:
摘要: Glioblastoma (GB) is the most lethal brain tumor due to its high proliferation, aggressiveness, infiltration capacity and resilience current treatments. Activation of Wingless-related-integration-site (WNT) pathway associated with a bad prognosis. Using Drosophila primary xenograft models human GB, we describe mechanism that leads activation WNT signaling [Wingless (Wg) in Drosophila] cells. GB cells display network microtubes (TMs) which enwraps neurons, accumulates Wg receptor Frizzled1 (Fz1), and, thereby, actively depletes from neurons. Consequently, proliferate β-catenin activation, neurons degenerate extinction. This novel view explains both neuron-dependent progression, also neural decay GB.
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