The function of RNA-binding proteins at the synapse: implications for neurodegeneration

摘要: The loss of synapses is a central event in neurodegenerative diseases. Synaptic proteins are often associated with disease neuropathology, but their role synaptic not fully understood. Of the many processes involved sustaining integrity synapses, local protein translation can directly impact formation, communication, and maintenance. RNA-binding association RNA granules serve to regulate mRNA transportation at turn synapse. Genetic mutations FUS TDP-43 have been linked causing diseases: amyotrophic lateral sclerosis frontotemporal dementia. observation that coincide changes provides evidence dysfunction metabolism may underlie mechanism these However, we do know how would affect granule dynamics translation, or if alterations cause neurodegeneration. Further investigation into this area will lead important insights disruption