mRNA Localization: An Orchestration of Assembly, Traffic and Synthesis
作者： Lei Xing , Gary J. Bassell
DOI: 10.1111/TRA.12004
关键词:
摘要: Asymmetrical mRNA localization and subsequent local translation provide efficient mechanisms for protein sorting in polarized cells. Defects have been linked to developmental abnormalities neurological diseases. Thus, it is critical understand the machineries mediating underlying asymmetrical distribution of its regulation. The goal this review summarize recent advances understanding transport localization, including assembly messenger ribonucleic (mRNP) granules, molecular active mRNP transport, cytoskeletal interactions regulation these events by extracellular signals.
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