Identification ofcis-Acting Sequences That ControlnanosRNA Localization

摘要: The generation of anterior-posterior polarity during development in Drosophila requires the localization determinant molecules to anterior and posterior poles embryo. Localization maternally synthesized nanos RNA pole embryo is essential provide a source for gradient Nanos protein that directs abdomen formation. occurs oogenesis function at least nine genes. cis-acting sequences direct lie within 3'UTR. In this analysis, we have used 3'UTR deletion mutants define signal more precisely. Our results indicate large complex targeting may be achieved by combined effects multiple, partially independent sequences. This idea supported evolutionary conservation, both sequence function, 3'UTRs melanogaster virilis.