Tyrosine kinase inhibition reverses TDP-43 effects on synaptic protein expression, astrocytic function and amino acid dis-homeostasis
作者： Lanier Heyburn , Michaeline L. Hebron , Jacqueline Smith , Charisse Winston , John Bechara
DOI: 10.1111/JNC.13763
关键词:
摘要: The trans‐activating response of DNA/RNA‐binding protein (TDP)‐43 pathology is associated with many neurodegenerative diseases via unknown mechanisms. Here, we use a transgenic mouse model over‐expressing human wild‐type neuronal TDP‐43 to study the effects of TDP‐43 pathology on glutamate metabolism and synaptic function. We found that neuronal TDP‐43 over‐expression affects synaptic protein expression, including Synapsin I, and alters surrounding astrocytic function. TDP‐43 over‐expression is associated with an …
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