An Adult Drosophila Glioma Model for Studying Pathometabolic Pathways of Gliomagenesis

作者: Kuan-Cheng Chi , Wen-Chiuan Tsai , Chia-Lin Wu , Tzu-Yang Lin , Dueng-Yuan Hueng

DOI: 10.1007/S12035-018-1392-2

关键词:

摘要: … Taken together, our novel adult fly glioma model identified a key cholesterol metabolic enzyme ACAT1, which regulates EGFR-PI3K–dependent gliomagenesis in vivo. …

参考文章(48)
Timothy P. Kegelman, Bin Hu, Luni Emdad, Swadesh K. Das, Devanand Sarkar, Paul B. Fisher, In vivo modeling of malignant glioma: the road to effective therapy. Advances in Cancer Research. ,vol. 121, pp. 261- 330 ,(2014) , 10.1016/B978-0-12-800249-0.00007-X
Andrew J Gentles, Aaron M Newman, Chih Long Liu, Scott V Bratman, Weiguo Feng, Dongkyoon Kim, Viswam S Nair, Yue Xu, Amanda Khuong, Chuong D Hoang, Maximilian Diehn, Robert B West, Sylvia K Plevritis, Ash A Alizadeh, The prognostic landscape of genes and infiltrating immune cells across human cancers Nature Medicine. ,vol. 21, pp. 938- 945 ,(2015) , 10.1038/NM.3909
Dueng-Yuan Hueng, Wen-Chiuan Tsai, Hsin-Ying Chiou, Shao-Wei Feng, Chin Lin, Yao-Feng Li, Li-Chun Huang, Ming-Hong Lin, DDX3X Biomarker Correlates with Poor Survival in Human Gliomas. International Journal of Molecular Sciences. ,vol. 16, pp. 15578- 15591 ,(2015) , 10.3390/IJMS160715578
J GARGANO, I MARTIN, P BHANDARI, M GROTEWIEL, Rapid iterative negative geotaxis (RING): a new method for assessing age-related locomotor decline in Drosophila. Experimental Gerontology. ,vol. 40, pp. 386- 395 ,(2005) , 10.1016/J.EXGER.2005.02.005
Chien-Min Chen, Dueng-Yuan Hueng, Yen-Po Cheng, Chin Lin, Ping-Yi Lin, Chun-Yuan Cheng, Hsin-I Ma, Midkine expression in high grade gliomas: Correlation of this novel marker with proliferation and survival in human gliomas. Surgical Neurology International. ,vol. 5, pp. 78- 78 ,(2014) , 10.4103/2152-7806.133205
E. M. Sizoo, L. Braam, T. J. Postma, H. R. W. Pasman, J. J. Heimans, M. Klein, J. C. Reijneveld, M. J. B. Taphoorn, Symptoms and problems in the end-of-life phase of high-grade glioma patients Neuro-oncology. ,vol. 12, pp. 1162- 1166 ,(2010) , 10.1093/NEUONC/NOP045
Gemma Llaverías, Juan C. Laguna, Marta Alegret, Pharmacology of the ACAT inhibitor avasimibe (CI-1011). Cardiovascular Drug Reviews. ,vol. 21, pp. 33- 50 ,(2006) , 10.1111/J.1527-3466.2003.TB00104.X
Mami Ikenoya, Yasunobu Yoshinaka, Hideyuki Kobayashi, Katsumi Kawamine, Kimiyuki Shibuya, Fumiyasu Sato, Kimio Sawanobori, Takuya Watanabe, Akira Miyazaki, A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels Atherosclerosis. ,vol. 191, pp. 290- 297 ,(2007) , 10.1016/J.ATHEROSCLEROSIS.2006.05.048
Renee D. Read, Webster K. Cavenee, Frank B. Furnari, John B. Thomas, A Drosophila Model for EGFR-Ras and PI3K-Dependent Human Glioma PLoS Genetics. ,vol. 5, pp. e1000374- ,(2009) , 10.1371/JOURNAL.PGEN.1000374
Silviu Sbiera, Ellen Leich, Gerhard Liebisch, Iuliu Sbiera, Andreas Schirbel, Laura Wiemer, Silke Matysik, Carolin Eckhardt, Felix Gardill, Annemarie Gehl, Sabine Kendl, Isabel Weigand, Margarita Bala, Cristina L. Ronchi, Timo Deutschbein, Gerd Schmitz, Andreas Rosenwald, Bruno Allolio, Martin Fassnacht, Matthias Kroiss, Mitotane Inhibits Sterol-O-Acyl Transferase 1 Triggering Lipid-Mediated Endoplasmic Reticulum Stress and Apoptosis in Adrenocortical Carcinoma Cells Endocrinology. ,vol. 156, pp. 3895- 3908 ,(2015) , 10.1210/EN.2015-1367