Midkine expression in high grade gliomas: Correlation of this novel marker with proliferation and survival in human gliomas.

摘要: BACKGROUND High-grade primary glioma have poor prognosis and predictive biomarkers is very important. Midkine (MDK), a heparin-binding growth factor, important in regulating carcinogenesis, cell proliferation, mitogenesis, angiogenesis. This study aimed to identify over-expression of MDK gliomas correlate this with clinical outcomes. The authors put forward their hypothesis correlating proliferation survival novel protein. METHODS Two datasets from Gene Expression Omnibus (GEO) included human data 100 180 patients, respectively. expression, World Health Organization (WHO) pathological grade, sex, age, time were identified for statistical analysis. RESULTS A search the GEO profile revealed that expression level was statistically greater WHO grade IV compared II (P = 0.002), grades III nontumor control 0.044 P < 0.001, respectively) after adjustments using Bonferroni method. By Kaplan-Meier curve, high group had poorer outcome (2.38-fold hazard, 95% confidence interval: 1.22-4.63) than low age. CONCLUSIONS Taken together, there positive correlation between grading gliomas. Moreover, significant correlated high-grade, suggesting may be an therapeutic target.