Prognostic value of Midkine expression in patients with solid tumors: a systematic review and meta-analysis

摘要: // Luo Zhang 1 , Xing Song Yingjie Shao Changping Wu 2 and Jingting Jiang Department of Tumor Biological Treatment, The Third Affiliated Hospital Soochow University, Changzhou, Jiangsu Province, China Oncology, Correspondence to: Wu, email: wcpjjt@163.com Jiang, jiangjingting@suda.edu.cn Keywords: Midkine; prognosis; solid tumor; meta-analysis Received: September 01, 2017      Accepted: November 13, Epub: January 04, 2018      Published: May 15, 2018 ABSTRACT Background: Accumulated studies have shown the important role Midkine (MDK) protein in various tumors indicated its correlation with patients’ survival. This was performed to further explore prognostic value MDK expression tumors. Materials Methods: We collected literatures through searching PubMed, Embase Cochrane Library (last up April 10, 2017) assess effect on survival tumor patients. STATA 12.0 software used for meta-analysis. Fixed-effects models or random-effects were estimate pooled hazard ratios (HRs) overall (OS). Results: A total 2097 patients from 17 observational summarized. High notably associated worse OS (pooled HR = 1.96; 95% CI 1.67–2.31). subgroup analysis type demonstrated negative impact elevated most ( P < 0.05), while had no relevance OSCC 1.68; 0.84–3.36; 0.145) HNSCC 1.56; 0.96–2.51; 0.075). Conclusions: present clarifies that is a potential biomarker Future large-scale prospective clinical trials are needed determine