A MAP of tumor-host interactions in glioma at single cell resolution
作者： Francesca Pia Caruso , Luciano Garofano , Fulvio D’Angelo , Kai Yu , Fuchou Tang
DOI: 10.1101/827758
关键词:
摘要: ABSTRACT Single-cell RNA sequencing is the reference technique to characterize heterogeneity of tumor microenvironment and can be efficiently used discover cross-talk mechanisms between immune cells cancer cells. We present a novel method, single cell Tumor-Host Interaction tool (scTHI), identify significantly activated ligand-receptor interactions across clusters from single-cell data. apply our approach uncover in glioma using six publicly available human datasets encompassing 71 patients. provide comprehensive map signalling malignant non-malignant uncovering potential therapeutic targets.
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