Increased midkine gene expression in childhood B-precursor acute lymphoblastic leukemia
作者： Hirokazu Hidaka , Hiroshi Yagasaki , Yoshiyuki Takahashi , Asahito Hama , Nobuhiro Nishio
DOI: 10.1016/J.LEUKRES.2006.12.008
关键词:
摘要: Midkine (MK) is a heparin-binding growth factor that overexpressed in number of solid cancers. However, expression acute leukemia has not been clarified. We examined MK gene using real-time PCR 94 children with leukemia. In 30 the 41 patients B-precursor ALL, was than normal BM. also more half FAB M1 and M2 types AML. Quantification by offers particular promise as prognostic marker for minimal residual disease ALL.
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