An Angiogenic Role for the Neurokines Midkine and Pleiotrophin in Tumorigenesis

摘要: Recent analysis of bladder tumors has correlated expression the neurokine midkine (MK) with poor patient survival. To examine a role for MK and related pleiotrophin (PTN) in tumorigenesis, they were overexpressed MCF-7 breast carcinoma cells. Expression had no effect on vitro growth but conferred advantage vivo. Enhanced tumor increased vascular density endothelial proliferation, implicating an angiogenic PTN. Angiogenic activity PTN was confirmed rabbit corneal assay. Our data therefore identify two novel targets antiangiogenic drug development.