The midkine family in cancer, inflammation and neural development.
作者： Kenji Kadomatsu
DOI: 10.18999/NAGJMS.67.3-4.71
关键词:
摘要: The midkine (MK) family consists of only two members, namely MK and pleiotrophin (PTN). PTN share receptors biophysical characteristics, such as a heparin-binding property. exert several biological activities, which include fibrinolytic, anti-apoptotic, mitogenic, transforming, angiogenic, chemotactic ones. These activities suggest that these growth factors are involved in carcinogenesis. Indeed, strong expression human carcinomas, the anti-tumor activity antisense oligonucleotides for ribozymes further support their importance cancer. In addition, plays critical roles pathogeneses various disorders involving inflammation reperfusion- cisplatin-induced renal dysfunction vascular restenosis after angioplasty. oligonucleotide ameliorates disorders. Zebrafish Xenopus can induce neural tissues. localized radial glial processes embryonic brain, induced reactive astrocytes by ischemic insults. I summarize here significance cancer, development.
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