摘要: Prostate cancer is the most common malignancy in developed countries. Midkine expressed prostate but not normal prostate, indicating that midkine can be used as a biomarker for diagnosis of cancer. The levels expression are higher late stage and metastatic tumors compared to early tumors, hinting at potential use prognostic biomarker. However, no study has been conducted evaluate serum or prognosis increased several castration resistant cell lines, suggesting possible role development upregulated by growth factors cytokines including tumor necrosis factor α androgens. shown activate extracellular signal regulated kinase (ERK1/2) p38 pathways, which associated with cellular survival LNCaP cells. siRNA antisense oligos have inhibit PC3 vitro vivo, appears synergize chemotherapeutical drug paclitaxel. C-terminal peptides, small molecular weight compounds, humanized monoclonal neutralizing antibodies hold prevention treatment
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Kenji Kadomatsu, The midkine family in cancer, inflammation and neural development. Nagoya Journal of Medical Science. ,vol. 67, pp. 71- 82 ,(2005) , 10.18999/NAGJMS.67.3-4.71
Shawn M. Brisbay, Timothy J. McDonnell, Patricia Troncoso, Leland W. K. Chung, Martin L. Campbell, Jer-Tsong Hsieh, Shi-Ming Tu, Christopher Logothetis, Expression of the Protooncogene bcl-2 in the Prostate and Its Association with Emergence of Androgen-independent Prostate Cancer Cancer Research. ,vol. 52, pp. 6940- 6944 ,(1992)
Noah Craft, Yuriy Shostak, Michael Carey, Charles L. Sawyers, A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase. Nature Medicine. ,vol. 5, pp. 280- 285 ,(1999) , 10.1038/6495
Lucy J. Schmidt, Horacio Murillo, Donald J. Tindall, Gene Expression in Prostate Cancer Cells Treated With the Dual 5 Alpha-Reductase Inhibitor Dutasteride Journal of Andrology. ,vol. 25, pp. 944- 953 ,(2004) , 10.1002/J.1939-4640.2004.TB03166.X
Norbert Gretz, Thomas Knoll, Annette Steidler, Maurice Stephan Michel, Lutz Trojan, Peter Alken, Axel Schaaf, Georg Thalmann, Markus Haak, Identification of metastasis-associated genes in prostate cancer by genetic profiling of human prostate cancer cell lines. Anticancer Research. ,vol. 25, pp. 183- 191 ,(2005)
Kazuyoshi Uehara, Shyuichiro Matsubara, Kenji Kadomatsu, Jun-ichiro Tsutsui, Takashi Muramatsu, Genomic Structure of Human Midkine (MK), a Retinoic Acid-Responsive Growth/Differentiation Factor Journal of Biochemistry. ,vol. 111, pp. 563- 567 ,(1992) , 10.1093/OXFORDJOURNALS.JBCHEM.A123797
Christian Radmayr, Alfred Hobisch, Jan Trapman, Georg Bartsch, Anton Hittmair, Helmut Klocker, Zoran Culig, Marcus V. Cronauer, Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor Cancer Research. ,vol. 54, pp. 5474- 5478 ,(1994)
Brigid Orr, Griet Vanpoucke, O. Cathal Grace, Lee Smith, Richard A. Anderson, Antony C.P. Riddick, Omar E. Franco, Simon W. Hayward, Axel A. Thomson, Expression of pleiotrophin in the prostate is androgen regulated and it functions as an autocrine regulator of mesenchyme and cancer associated fibroblasts and as a paracrine regulator of epithelia. The Prostate. ,vol. 71, pp. 305- 317 ,(2011) , 10.1002/PROS.21244
Maria Hatziapostolou, Jean Delbe, Panagiotis Katsoris, Christos Polytarchou, Jose Courty, Evangelia Papadimitriou, Heparin affin regulatory peptide is a key player in prostate cancer cell growth and angiogenicity. The Prostate. ,vol. 65, pp. 151- 158 ,(2005) , 10.1002/PROS.20270
Francis Vacherot, Khalid Laaroubi, Daniele Caruelle, Jean Delbe, Denis Barritault, Jean Pierre Caruelle, José Courty, Upregulation of heparin-affin regulatory peptide by androgen In Vitro Cellular & Developmental Biology – Animal. ,vol. 31, pp. 647- 648 ,(1995) , 10.1007/BF02634082