Midkine induces epithelial-mesenchymal transition through Notch2/Jak2-Stat3 signaling in human keratinocytes.

摘要: Epithelial-to-mesenchymal transition (EMT) underlies cell plasticity and embryonic development is frequently observed in advanced tumorigenesis. We demonstrated that midkine (MK), a retinoic acid-inducible heparin-binding mitogen, promotes EMT immortalized HaCaT keratinocytes. showed MK binds to the Notch2 receptor further found activates signaling leading protein/protein interactions between Hes1 Jak2/Stat3 intermediates. thus suggest MK-induced cross talk of Notch2/Jak2/Stat3 pathways can regulate motility contributing later stages