Tobacco Smoke Activates Protein Association and Tyrosine Phosphorylation of the GPI-Transamidase Complex Subunits in Human Cancers

作者: Yiping Huang , Jatin Nagpal , Barry Trink , Edward Ratovitski

DOI: 10.2174/1875044300902010014

关键词:

摘要: We previously found that the protein subunits of GPI-transamidase complex (e.g. PIG-U, PIG-T and GPAA1) play critical roles oncogenes in human bladder breast cancers manifesting their activities through signaling mecha- nisms involve urokinase receptor/Stat3 paxillin pathways. report here cigarette smoke extract (CSE) en- hanced colony formation invasiveness certain cancer cells head neck, or breast). CSE induced between GPAA1 proteins also association EGFR cells. observed inhibitors tyrosine kinase, Gefitinib Erlotinib, modu- lated phosphorylation PIG-U by CSE. kinase siRNA silencing modulated CSE-induced increase invasive- ness suggest novel mechanism overlapping oncogenic potential implicates subsequent phosphoryla- tion.

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