Nicotine decreases the cytotoxicity of doxorubicin towards MCF-7 and KB-3.1 human cancer cells in culture.

摘要: The harmful effects of tobacco use and nicotine are well known. There is strong epidemiological evidence for smoking as a risk factor cancer the lung oral cavity. second-hand smoke breast rapidly accumulating. anthracycline doxorubicin used in treatment many types malignancies, including cancer. effect on toxicity was evaluated MCF-7 KB-3.1 cell cultures. Nicotine partially inhibited towards cells, judged by clonogenicity flow cytometry assays. Flow cytometric analysis showed that < 10% cells treated with underwent apoptosis, while necrosis major mode death. Inhibition apoptosis can diminish effectiveness therapy.