Modeling human brain tumours in flies, worms, and zebrafish: From proof of principle to novel therapeutic targets
作者： Uswa Shahzad , Michael S Taccone , Sachin A Kumar , Hidehiro Okura , Stacey Krumholtz
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摘要: For decades, cell biologists and cancer researchers have taken advantage of non-murine species to increase our understanding the molecular processes that drive normal tissue development, when perturbed, cause cancer. The advent whole-genome sequencing has revealed high genetic homology these organisms humans. Seminal studies in such as Drosophila melanogaster, Caenorhabditis elegans, Danio rerio identified many signaling pathways involved Studies offer distinct advantages over mammalian or murine systems. Compared models, three shorter lifespans, are less resource intense, amenable high-throughput drug RNA interference screening test a myriad promising drugs against novel targets. In this review, we introduce species-specific breeding strategies, highlight modeling brain tumors each non-mammalian species, underscore successes attributed scientific investigation using models. We conclude with an optimistic proposal discoveries fields research, particular neuro-oncology, may be expedited powerful tools strategies.
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