Cell of origin of glioma: biological and clinical implications.

摘要: The cellular origin of gliomas remains a topic controversy in cancer research. Advances neurobiology, molecular genetics, and functional genomics have ushered new insights through exploiting the development more sophisticated tools to address this question. Diverse distinct cell populations adult brain been reported give rise gliomas, although how these studies relate physiologically mechanisms spontaneous tumour formation via accumulation tumour-initiating mutations within single are less well developed. Recent animal models indicate that lineage may contribute biological genomic phenotype glioblastoma. These results suggest not only serve as source diversity for tumours, but also provide avenues improved diagnostics therapeutic targeting prolong lives patients.