Subtypes of medulloblastoma have distinct developmental origins

作者: Paul Gibson , Yiai Tong , Giles Robinson , Margaret C. Thompson , D. Spencer Currle

DOI: 10.1038/NATURE09587

关键词:

摘要: Medulloblastoma encompasses a collection of clinically and molecularly diverse tumour subtypes that together comprise the most common malignant childhood brain tumour 1 , 2 , 3 , 4 …

参考文章(29)
Cynthia Wetmore, Tom Curran, Derek E. Eberhart, Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched. Cancer Research. ,vol. 61, pp. 513- 516 ,(2001)
Jos Jonkers, Ralph Meuwissen, Hanneke van der Gulden, Hans Peterse, Martin van der Valk, Anton Berns, Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nature Genetics. ,vol. 29, pp. 418- 425 ,(2001) , 10.1038/NG747
Ulrich Schüller, Vivi M. Heine, Junhao Mao, Alvin T. Kho, Allison K. Dillon, Young-Goo Han, Emmanuelle Huillard, Tao Sun, Azra H. Ligon, Ying Qian, Qiufu Ma, Arturo Alvarez-Buylla, Andrew P. McMahon, David H. Rowitch, Keith L. Ligon, Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell. ,vol. 14, pp. 123- 134 ,(2008) , 10.1016/J.CCR.2008.07.005
Robert A Johnson, Karen D Wright, Helen Poppleton, Kumarasamypet M Mohankumar, David Finkelstein, Stanley B Pounds, Vikki Rand, Sarah ES Leary, Elsie White, Christopher Eden, Twala Hogg, Paul Northcott, Stephen Mack, Geoffrey Neale, Yong-Dong Wang, Beth Coyle, Jennifer Atkinson, Mariko DeWire, Tanya A Kranenburg, Yancey Gillespie, Jeffrey C Allen, Thomas Merchant, Fredrick A Boop, Robert A Sanford, Amar Gajjar, David W Ellison, Michael D Taylor, Richard G Grundy, Richard J Gilbertson, None, Cross-species genomics matches driver mutations and cell compartments to model ependymoma Nature. ,vol. 466, pp. 632- 636 ,(2010) , 10.1038/NATURE09173
Lisa V. Goodrich, Ljiljana Milenković, Kay M. Higgins, Matthew P. Scott, Altered Neural Cell Fates and Medulloblastoma in MousepatchedMutants Science. ,vol. 277, pp. 1109- 1113 ,(1997) , 10.1126/SCIENCE.277.5329.1109
R. Storm, J. Cholewa-Waclaw, K. Reuter, D. Brohl, M. Sieber, M. Treier, T. Muller, C. Birchmeier, The bHLH transcription factor Olig3 marks the dorsal neuroepithelium of the hindbrain and is essential for the development of brainstem nuclei. Development. ,vol. 136, pp. 295- 305 ,(2009) , 10.1242/DEV.027193
X. Huang, J. Liu, T. Ketova, J. T. Fleming, V. K. Grover, M. K. Cooper, Y. Litingtung, C. Chiang, Transventricular delivery of Sonic hedgehog is essential to cerebellar ventricular zone development. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 107, pp. 8422- 8427 ,(2010) , 10.1073/PNAS.0911838107
Anna F. Farago, Rajeshwar B. Awatramani, Susan M. Dymecki, Assembly of the Brainstem Cochlear Nuclear Complex Is Revealed by Intersectional and Subtractive Genetic Fate Maps Neuron. ,vol. 50, pp. 205- 218 ,(2006) , 10.1016/J.NEURON.2006.03.014
Rebecca L. Landsberg, Rajeshwar B. Awatramani, Nina L. Hunter, Anna F. Farago, Heather J. DiPietrantonio, Carolyn I. Rodriguez, Susan M. Dymecki, Hindbrain rhombic lip is comprised of discrete progenitor cell populations allocated by Pax6. Neuron. ,vol. 48, pp. 933- 947 ,(2005) , 10.1016/J.NEURON.2005.11.031