Primary Cilia and Brain Cancer
作者： Shirui Hou , Young-Goo Han
DOI: 10.1007/978-94-007-5808-7_8
关键词: Cilium 、 Receptor tyrosine kinase 、 Cell cycle 、 Cancer 、 Wnt signaling pathway 、 Cell biology 、 Hedgehog 、 Biology 、 Cell 、 Mutation
摘要: Cell-extrinsic signals and intrinsic cell cycle regulators strictly control proliferation. Cancers develop from a that escapes these tight controls proliferates unrestrictedly. The primary cilium critically proliferation by mediating cell-extrinsic regulating entry. Accordingly, recent studies showed defective cilia can either promote or suppress cancers, depending on the cancer-initiating mutation, presence absence of is associated with specific cancer types. These novel findings suggest play central but distinct roles in different types, opening up completely new avenue research to understand biology treatment cancers.
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